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Systemisch wirksame Antimykotika

Polyen                  
                        Amphotericin B Deoxycholat
                      • Liposomales Ampho B (Ambisome®)
                      • ABCD (Amphocil®)
                      • ABLC (Abelcet®)
Pyrimidin
                        5-Fluorocytosin (Ancotil®)
Imidazole
                        Miconazol (Daktar®)
                        Ketoconazol (Nizoral®)
                        Fluconazol (Diflucan®)
                        Itraconazol (Sempera®)
                        Voriconazol (Vfend®)
Echinocandin            
                        Caspofungin (Cancidas®)
Allylamin               
                        Terbinafin (Lamisil®)

Aspergillus Infektionen

Therapie der invasive Aspergillus-Pneumonie

  • Voriconazol Vfend 2 x 4 mg/ kg/ Tag (loading dose 2 x 6 mg/ kg/ Tag)
  • Amphotericin B 0,8 – 1 mg/ kg/ Tag,
  • Lipo Amphotericin B 3 - 6 mg/ kg/ Tag
    • Alternativ: Caspofungin 50 mg (loading 70 mg)
    • Nachbehandlung: Voriconazol, Itraconazol

Oral

Mykosen

  • Aspergillus spp.
  • Candida spp.
  • Pneumocystis jiroveci
  • Cryptosporidium spp.
  • Cryptococcus spp.

Aspergillose

Diagnostik

  • direkter Erregernachweis (positive Sputumkultur, Bronchoalveoläre Lavage, Biopsie)
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